Browsing William Harvey Research Institute by Title
Now showing items 2663-2682 of 4740
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M3C: Monte Carlo reference-based consensus clustering
(bioRxiv, 2019-12-04)Abstract: Genome-wide data is used to stratify patients into classes for precision medicine using clustering algorithms. A common problem in this area is selection of the number of clusters (K). The Monti consensus clustering ... -
M3C: Monte Carlo reference-based consensus clustering.
(2020-02-04)Genome-wide data is used to stratify patients into classes for precision medicine using clustering algorithms. A common problem in this area is selection of the number of clusters (K). The Monti consensus clustering algorithm ... -
Machine Learning of Cardiac Anatomy and the Risk of New-Onset Atrial Fibrillation After TAVR.
(2024-05-16)BACKGROUND: New-onset atrial fibrillation (NOAF) occurs in 5% to 15% of patients who undergo transfemoral transcatheter aortic valve replacement (TAVR). Cardiac imaging has been underutilized to predict NOAF following TAVR. ... -
Macro-GH - A clinical entity causing a diagnostic challenge - A case report.
(2023-06-01)AIM: Presentation of a new case of a patient with macro-GH, that may interfere with different GH assays leading to false-positive results in serum samples. CASE PRESENTATION: A 61-year-old female was referred with a pituitary ... -
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
(2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Macrophage diversity in cancer dissemination and metastasis.
(2024-11)Invasion and metastasis are hallmarks of cancer. In addition to the well-recognized hematogenous and lymphatic pathways of metastasis, cancer cell dissemination can occur via the transcoelomic and perineural routes, which ... -
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
(2018-01-30)The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ... -
Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production.
(Royal Society of Chemistry, 2020-03-25)Nanoengineered vehicles have the potential to deliver cargo drugs directly to disease sites, but can potentially be cleared by immune system cells or lymphatic drainage. In this study we explore the use of magnetism to ...