Browsing William Harvey Research Institute by Title
Now showing items 2241-2260 of 4279
-
KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.
(2019-12-05)BACKGROUNDThe presence of an early repolarization pattern (ERP) on the surface ECG is associated with risk of ventricular fibrillation and sudden cardiac death. Family studies have shown that ERP is a highly heritable ... -
Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study.
(Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics, 2018-11-05)Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of a uniform high standard. As there are currently no uniform ... -
The kindlin family: functions, signaling properties and implications for human disease
(The Company of Biologists, 2016-01-01) -
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
(Springer Science and Business Media LLC, 2014-04) -
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
<jats:p>Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking ... -
Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells
(Rockefeller University Press, 2015-08-24)<jats:p>Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become ...
