Browsing William Harvey Research Institute by Title
Now showing items 397-416 of 3954
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B cell depletion with rituximab in the treatment of primary Sjögren's syndrome: what have we learnt?
(2019-05)Despite the well-established role of B cells in the pathogenesis of primary Sjögren's syndrome (pSS), the beneficial role of B-cell depletion therapy with rituximab remains elusive in this condition, contrary to other ... -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
(2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
(2020-04)Meeting abstract P233 from British Society for Rheumatology Annual Conference 2020 -
B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.
(Elsevier, 2019-02-22)TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation. • TLS can be destructive or have beneficial effects ... -
Babelomics 5.0: functional interpretation for new generations of genomic data
(Oxford University Press, 2015-07-01)Babelomics has been running for more than one decade offering a user-friendly interface for the functional analysis of gene expression and genomic data. Here we present its fifth release, which includes support for Next ... -
Balloon-Expandable TAVR Bioprostheses: Area or Perimeter Sizing? A Prospective Pilot Study.
(2022)OBJECTIVE: In TAVR, area sizing is used for balloon-expandable (BE) valves, whereas self-expanding valves are sized to annulus perimeter. For BE valves, this seems illogical: these frames force a circular shape even on an ... -
The Bare Minimum: The Reality of Global Anaesthesia and Patient Safety
(Springer International Publishing, 2016-06-01) -
Baroreflex impairment and morbidity after major surgery
(Elsevier Ltd., 2016-09)Background Baroreflex dysfunction is a common feature of established cardiometabolic diseases that are most frequently associated with the development of critical illness. Laboratory models show that baroreflex dysfunction ... -
Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale
(BMC (part of Springer Nature), 2019-09-02)Background Rodent models are invaluable for studying biological processes in the context of whole organisms. The reproducibility of such research is based on an assumption of metabolic similarity between experimental ... -
BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a
(BMJ Publishing Group, 2020-05-05)Objective Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and known to be associated to ...
