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FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.

Teh, MT; Gemenetzidis, E; Patel, D; Tariq, R; Nadir, A; Bahta, AW; Waseem, A; Hutchison, IL (2012)

The oncogene FOXM1 has been implicated in all major types of human cancer. We recently showed that aberrant FOXM1 expression causes stem cell compartment expansion resulting in the initiation of hyperplasia. We have ...

Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling

Bose, A; Teh, MT; Hutchison, IL; Wan, H; Leigh, IM; Waseem, A (2012)

Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles. However, in certain clinical situations ...

To treat...or not to treat? Clinicians' views on the management of oral potentially malignant disorders.

Thomson, PJ; McCaul, JA; Ridout, F; Hutchison, IL (2015-12)

Oral potentially malignant disorders (PMD) are recognisable mucosal conditions that have a variable and unpredictable risk of transformation to invasive squamous cell carcinoma (SCC). Modern management relies initially on ...

Management of the clinically N0 neck in early-stage oral squamous cell carcinoma (OSCC). An EACMFS position paper.

Vassiliou, LV; Acero, J; Gulati, A; Hölzle, F; Hutchison, IL; Prabhu, S; Testelin, S; Wolff, K-D; Kalavrezos, N (2020-08)

Metastasis of oral squamous cell carcinoma (OSCC) to the cervical lymph nodes has a significant impact on prognosis. Accurate staging of the neck is important in order to deliver appropriate treatment for locoregional ...