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Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants.
(2017-11-02)
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe ...
Mortality, HIV transmission and growth in children exposed to HIV in rural Zimbabwe.
(2020-01-24)
BACKGROUND: Although prevention of mother-to-child transmission (PMTCT) interventions have substantially reduced vertical HIV infection in sub-Saharan Africa, mortality and growth among children who are HIV-exposed remain ...
Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy
(Oxford University Press, 2016-05-18)
Background. Identifying determinants of morbidity and mortality may help target future interventions for human immunodeficiency virus (HIV)–infected children.
Methods. CD4+ T-cell count, HIV viral load, and levels of ...
Predictors of oral rotavirus vaccine immunogenicity in rural Zimbabwean infants.
(Elsevier, 2020-03-17)
BACKGROUND: Oral rotavirus vaccines (RVV) have poor immunogenicity in low-income countries, for reasons that remain unclear. This study identified the determinants of RVV immunogenicity among infants in rural Zimbabwe. ...
The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa.
(Oxford University Press, 2019-10-23)
Cotrimoxazole prophylaxis reduces morbidity and mortality among people living
with human immunodeficiency virus
(HIV) in sub-Saharan Africa, regardless
of age, degree of immunosuppression,
disease stage, or duration ...
Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.
(Oxford University Press, 2019-01-01)
Objective: Immune activation is associated with morbidity and mortality during human immunodeficiency virus (HIV) infection, despite receipt of antiretroviral therapy (ART). We investigated whether microbial translocation ...
Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the preantiretroviral therapy era
(Lippincott, Williams & Wilkins, 2016-09-24)
Objectives: To describe the head growth of children according to maternal and child
HIV infection status.
Design: Longitudinal analysis of head circumference data from 13 647 children
followed from birth in the ZVITAMBO ...
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial.
(Oxford University Press, 2018-03-04)
Background: Severely immunocompromised human immunodeficiency virus (HIV)-infected individuals have high mortality shortly after starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ...
