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The impact of improved water, sanitation and hygiene on oral rotavirus vaccine immunogenicity in Zimbabwean infants: sub-study of a cluster-randomized trial.
(Oxford University Press for the Infectious Diseases Society of America., 2019-02-16)
BACKGROUND: Oral vaccines have lower efficacy in developing compared to developed countries. Poor water, sanitation and hygiene (WASH) may contribute to reduced oral vaccine immunogenicity. METHODS: We conducted a ...
Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy
(Oxford University Press, 2016-05-18)
Background. Identifying determinants of morbidity and mortality may help target future interventions for human immunodeficiency virus (HIV)–infected children.
Methods. CD4+ T-cell count, HIV viral load, and levels of ...
Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants.
(2017-11-02)
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe ...
Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants.
(2018-12-20)
Background: Micronutrient deficiencies may contribute to reduced oral vaccine immunogenicity in developing countries. We hypothesised that neonatal vitamin A supplementation (NVAS) would improve oral vaccine responses. ...
Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study.
(Public Library of Science, 2018-03-22)
BACKGROUND: Rotavirus is the leading cause of acute gastroenteritis in children and is associated with neurological complications such as seizures and encephalopathy. The aim of this study was to investigate the presentation ...
The Human Microbiome and Child Growth – First 1000 Days and Beyond
(Elsevier - Cell Press, 2018-10-24)
The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this ...
Environmental enteric dysfunction pathways and child stunting: A systematic review.
(2018-01)
BACKGROUND: Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie ...
Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the preantiretroviral therapy era
(Lippincott, Williams & Wilkins, 2016-09-24)
Objectives: To describe the head growth of children according to maternal and child
HIV infection status.
Design: Longitudinal analysis of head circumference data from 13 647 children
followed from birth in the ZVITAMBO ...
