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Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
(Macmillan Press, 1987)
The involvement of 5-hydroxytryptamine (5-HT) 5-HT3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. Anti-emetic compounds tested were ...
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ...