Browsing Blizard Institute by Title
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C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
(Oxford University Press, 2020-09-04) -
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.
(2018-01-24)Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS). Here, through a combination of RNA-Seq and electrophysiological studies on induced pluripotent stem cell (iPSC)-derived motor ... -
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
(National Academy of Sciences, 2017-07-10)Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors (TAS2Rs). TAS2Rs are expressed in the mouth and in several extraoral ... -
Calibrating models of cancer invasion: parameter estimation using approximate Bayesian computation and gradient matching.
(2021-06-16)We present two different methods to estimate parameters within a partial differential equation model of cancer invasion. The model describes the spatio-temporal evolution of three variables-tumour cell density, extracellular ...