Browsing Blizard Institute by Title

The A150V polymorphism of genotype 3 hepatitis C virus polymerase inhibits interferon alfa by suppressing protein kinase R activation.

Jason Lee, W-Y; Jones, M; Wing, PAC; Rajagopal, S; Foster, GR (2020-11-25)

BACKGROUND AND AIMS: Despite recent advances in antiviral therapy for HCV, a proportion of patients with genotype 3 (G3) HCV infection do not respond to current all oral treatment regimens [1,2]. Genomic analyses have ...

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

Rangarajan, S; Walsh, L; Lester, W; Perry, D; Madan, B; Laffan, M; Yu, H; Vettermann, C; Pierce, GF; Wong, WY (2017-12-28)

BACKGROUND: Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, soft tissue, and the central nervous system. Although successful gene transfer has been reported in patients with hemophilia ...

Ab Initio Atom-Atom Potentials Using CAMCASP: Theory and Application to Many-Body Models for the Pyridine Dimer

Misquitta, AJ; Stone, AJ (2016-09)

ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln347, Gln725, Gln990 to Confer Cellular Resistance to the Anticancer Drug Taxol

Sasitharan, K; Iqbal, HA; Bifsa, F; Olszewska, A; Linton, KJ (MDPI, 2021-08-09)

The multidrug efflux transporter ABCB1 is clinically important for drug absorption and distribution and can be a determinant of chemotherapy failure. Recent structure data shows that three glutamines donate hydrogen bonds ...

ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population

Andress, EJ; Nicolaou, M; McGeoghan, F; Linton, KJ (2017)

Abdominal Pain Presenting as a Tight Squeeze on a Tchaikovsky Score.

Ruffle, JK; Power, N; Aziz, Q (2018-09-18)

Abiraterone Acetate for the Treatment of Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: An Evidence Review Group Perspective of an NICE Single Technology Appraisal

Ramaekers, BLT; Riemsma, R; Tomini, F; van Asselt, T; Deshpande, S; Duffy, S; Armstrong, N; Severens, JL; Kleijnen, J; Joore, MA (2017-02)

Abnormal Perception of Urge to Defecate: An Important Pathophysiological Mechanism in Women With Chronic Constipation

Vollebregt, PF; Wiklendt, L; Burgell, RE; Chaichanavichkij, P; Dinning, PG; Knowles, CH; Scott, SM (2022)

Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas

Edmunds, SC; Cree, IA; Di Nicolantonio, F; Hungerford, JL; Hurren, JS; Kelsell, DP (2003-05-06)

Abstracts of the 38th International Conference on Pharmacoepidemiology: Advancing Pharmacoepidemiology and Real-World Evidence for the Global Community, August 26-28, 2022, Copenhagen, Denmark.

Unknown author (2022-09)

ABT-450/r/Ombitasvir plus Dasabuvir With or Without Ribavirin in HCV Genotype 1-infected Patients Receiving Stable Opioid Substitution Treatment: Pooled Analysis of Efficacy and Safety in Phase 2 and Phase 3 Trials

Puoti, M; Cooper, C; Sulkowski, MS; Foster, GR; Berg, T; Villa, E; Rodriguez-Perez, F; Rustgi, V; Wyles, DL; King, M (2014)

Acceptability of a theory-based adherence intervention for adults with asthma - a person-based approach

Katzer, CB; Mes, MA; Chan, AHY; Wileman, V; Taylor, SJC; Horne, R (2020-07-02)

Accounting for centre-effects in multicentre trials with a binary outcome - when, why, and how?

Kahan, BC (2014-02-10)

Accounting for overdispersion when determining primary care outliers for the identification of chronic kidney disease: learning from the National Chronic Kidney Disease Audit

Kim, LG; Caplin, B; Cleary, F; Hull, SA; Griffith, K; Wheeler, DC; Nitsch, D; Audit, UKNCKD (2017-04)

Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta-analysis.

Dos Santos, F; Daru, J; Rogozińska, E; Cooper, NAM (2018-06)

INTRODUCTION: Fetal fibronectin (fFN) is a validated test for assessing risk of preterm birth for women presenting with symptoms. Our aim was to evaluate the accuracy of fFN to detect the risk of preterm birth in asymptomatic ...

Accuracy of tests used to detect infection with Chlamydia trachomatis in asymptomatic pregnant women: a systematic review

Sahi, S-V; Rogozinska, E; Sobhy, S; Khan, KS (2017-12)

Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis

Pathak, N; Dodds, J; Zamora, J; Khan, K (2014-09-16)