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The evolutionary landscape of colorectal tumorigenesis
(2018-10)
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ...
Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer
(2019-05-03)
Colorectal cancer develops from its precursor lesion, the adenoma. The immune system is hypothesized to be key in modulating progression, but tumor-immune eco-evolutionary dynamics remain uncharacterized. Here, we demonstrate ...