Browsing Centre for Tumour Biology by Author "Barnes, CP"
Now showing items 1-8 of 8
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Catch my drift? Making sense of genomic intra-tumour heterogeneity
Sottoriva, A; Barnes, CP; Graham, TA (2017-04) -
Crypt fusion as a homeostatic mechanism in the human colon.
Baker, A-M; Gabbutt, C; Williams, MJ; Cereser, B; Jawad, N; Rodriguez-Justo, M; Jansen, M; Barnes, CP; Simons, BD; McDonald, SA (BMJ, 2019-03-14)OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove ... -
Identification of neutral tumor evolution across cancer types
Williams, MJ; Werner, B; Barnes, CP; Graham, TA; Sottoriva, A (2016-03) -
Measuring single cell divisions in human tissues from multi-region sequencing data.
Werner, B; Case, J; Williams, MJ; Chkhaidze, K; Temko, D; Fernández-Mateos, J; Cresswell, GD; Nichol, D; Cross, W; Spiteri, I (Nature Research (part of Springer Nature), 2020-02-25)Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in ... -
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.
Williams, MJ; Zapata, L; Werner, B; Barnes, CP; Sottoriva, A; Graham, TA (eLife Sciences Publications Ltd, 2020-03-30)The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in ... -
Quantification of subclonal selection in cancer from bulk sequencing data
Williams, MJ; Werner, B; Heide, T; Curtis, C; Barnes, CP; Sottoriva, A; Graham, TA (2018-06) -
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
Bollen, Y; Stelloo, E; van Leenen, P; van den Bos, M; Ponsioen, B; Lu, B; van Roosmalen, MJ; Bolhaqueiro, ACF; Kimberley, C; Mossner, M (2021-08)Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ... -
Subclonal reconstruction of tumors by using machine learning and population genetics
Caravagna, G; Heide, T; Williams, MJ; Zapata, L; Nichol, D; Chkhaidze, K; Cross, W; Cresswell, GD; Werner, B; Acar, A (2020-09)