Browsing Centre for Tumour Biology by Issue Date
Now showing items 21-40 of 364
-
A role for the cancer-associated miR-106b similar to 25 cluster in neuronal stem cells
(Impact Journals, 2011-04)In the last decade, micro-RNAs (miRNAs) have emerged as major regulators of cell fate. They are involved in fine-tuning gene expression in normal developing tissues and are often aberrantly expressed in different disease ... -
An unusual cause of gastrointestinal bleeding: duodenal lipoma.
(2011-04-13)Common causes of chronic upper gastrointestinal bleeding include oesophageal varices, gastroduodenal ulcers and malignancy, and patients mostly present with iron deficiency type anaemia. We present the case of a 60-year-old ... -
Rac1 Deletion Causes Thymic Atrophy
(2011-04-29) -
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
(Macmillan Publishers, 2012-06)Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidative stress. FOXOs have ... -
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
(Springer Verlag, 2013-01-23)BACKGROUND: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ... -
Antagonism between FOXO and MYC Regulates Cellular Powerhouse.
(Frontiers Media SA, 2013-04-25)Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis ...
