Browsing Centre for Molecular Oncology by Title
Now showing items 160-179 of 272
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Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial.
(Elsevier, 2021-10-14)BACKGROUND: No phase 3 trial has yet shown improved survival for patients with pleural or peritoneal malignant mesothelioma who have progressed following platinum-based chemotherapy. The aim of this study was to assess the ... -
Non-random Mis-segregation of Human Chromosomes.
(2018-06-12)A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations ... -
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation.
(Impact Journals, 2013-10-13)TSC2 (Tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. TSC2 protein complexes with ... -
A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer
(Elsevier (Cell Press), 2021-03-26)Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world, and there remains an urgent need to develop long-lasting therapies to treat CRC and prevent recurrence in patients. Oncolytic ... -
Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer.
(2017)Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have recently been the focus of extensive research aiming to develop their therapeutic potential. The ultimate aim is to design a virus ... -
Optimizing arginine deprivation for hard-to-treat cancers.
(2017-11-14)