Browsing Centre for Experimental Cancer Medicine by Title

Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term outcomes

Manchanda, R; Burnell, M; Gaba, F; Desai, R; Wardle, J; Gessler, S; Side, L; Sanderson, S; Loggenberg, K; Brady, AF (2020-02)

Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term secondary lifestyle behavioural outcomes

Burnell, M; Gaba, F; Sobocan, M; Desai, R; Sanderson, S; Loggenberg, K; Gessler, S; Side, L; Brady, AF; Dorkins, H (2022)

Recruitment, adherence, and retention of endometrial cancer survivors in a behavioural lifestyle programme: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomised pilot trial.

Koutoukidis, DA; Beeken, RJ; Manchanda, R; Michalopoulou, M; Burnell, M; Knobf, MT; Lanceley, A (2017-10-08)

OBJECTIVE: Healthy eating and physical activity may help endometrial cancer survivors (ECS) improve their quality of life. However, most ECS do not meet the relevant guidelines. This pilot trial aimed to test the study ...

Reply to Pontus Eriksson, Gottfrid Sjodahl, and Fredrik Liedberg's Letter to the Editor re: Thomas Powles, Robert A. Huddart, Tony Elliott, et al. Phase III, Double-blind, Randomized Trial that Compared Maintenance Lapatinib versus Placebo after First-line Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 1/2-positive Metastatic Bladder Cancer. J Clin Oncol 2017;35:48-55. Knowing HER2 Status is Not Enough: A Molecular Subtype Approach to Bladder Cancer is Also Needed <i>Protein Expression to Predict Outcome to Targeted Therapy in Bladder Cancer: Too Little, Too Late?</i>

Powles, T; de Liano, AG; Ackerman, C (2017)

Results of Annual Screening in Phase I of the United Kingdom Familial Ovarian Cancer Screening Study Highlight the Need for Strict Adherence to Screening Schedule

Rosenthal, AN; Fraser, L; Manchanda, R; Badman, P; Philpott, S; Mozersky, J; Hadwin, R; Cafferty, FH; Benjamin, E; Singh, N (2013-01-01)

RESULTS OF INTENSIVE ALGORITHM-BASED SCREENING IN THE UK FAMILIAL OVARIAN CANCER SCREENING STUDY (UK FOCSS PHASE 2)

Rosenthal, AN; Fraser, L; Philpott, S; Manchanda, R; Badman, P; Hadwin, R; Evans, DG; Eccles, D; Skates, S; Mackay, J (ESGO and IGCS., 2013-10)

Objectives To establish the performance of intensive screening for familial ovarian cancer using the risk of ovarian cancer algorithm (ROCA) and transvaginal sonogrpahy (TVS). Methods Between 14/06/2007 and 29/03/2012, ...

A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.

Jervis, S; Song, H; Lee, A; Dicks, E; Harrington, P; Baynes, C; Manchanda, R; Easton, DF; Jacobs, I; Pharoah, PPD (2015-07)

BACKGROUND: Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that considers the effects of BRCA1, BRCA2 and other ...

Risk Reducing Salpingectomy and Delayed Oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK

Chandrasekaran, D; Menon, U; Evans, G; Crawford, R; Saridogan, E; Jacobs, C; Tischkowitz, M; Brockbank, E; Kalsi, J; Jurkovic, D (Springer Verlag (Germany), 2015-07-16)

Risk-reducing-salpingectomy and Delayed-Oophorectomy (RRSDO) is being proposed as a two-staged approach in place of RRSO to reduce the risks associated with premature menopause in high-risk women. We report on the ...

Risk-reducing early salpingectomy and delayed oophorectomy as a two-staged alternative for primary prevention of ovarian cancer in women at increased risk: a commentary.

Gaba, F; Piek, J; Menon, U; Manchanda, R (2019-06)

RNA splicing and splicing regulator changes in prostate cancer pathology

Munkley, J; Livermore, K; Rajan, P; Elliott, DJ (2017-09)

Robotic and Advanced Laparoscopic Surgical Training in European Gynecological Oncology Trainees.

Gan, C; Bossart, M; Piek, J; Halaska, M; Haidopoulos, D; Zapardiel, I; Grabowski, JP; Kesic, V; Kimmig, R; Cibula, D (2017-02)

INTRODUCTION: Advanced minimal access surgical training is an important component of training in gynecological oncology (GO). Europe-wide data on this topic are lacking. We present data on availability and trainee experience ...

The role of angiogenic signatures in advanced urothelial carcinoma (aUC) treated with VEGF-targeted therapy

Jackson-Spence, FE; Ackerman, C; Khan, M; Grant, M; Soosaipillai, G; Nally, E; Choy, J; Powles, TB; Szabados, BE (2021)

The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer.

Manchanda, R; Drapkin, R; Jacobs, I; Menon, U (2012-02)

Screening of symptomatic women for ovarian cancer.

Gentry-Maharaj, A; Kalsi, J; Burnell, M; Manchanda, R; Menon, U (2012-04)

Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort

Jacobs, I; Gentry-Maharaj, A; Burnell, M; Manchanda, R; Singh, N; Sharma, A; Ryan, A; Seif, MW; Amso, NN; Turner, G (2011-01)

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Kanu, N; Groenroos, E; Martinez, P; Burrell, RA; Goh, XY; Bartkova, J; Maya-Mendoza, A; Mistrik, M; Rowan, AJ; Patel, H (2015-11-12)

Setting the Threshold for Surgical Prevention in Women at Increased Risk of Ovarian Cancer.

Manchanda, R; Menon, U (2018-01)

The number of ovarian cancer cases is predicted to rise by 14% in Europe and 55% worldwide over the next 2 decades. The current absence of a screening program, rising drug/treatment costs, and only marginal improvements ...

Should Opportunistic Bilateral Salpingectomy (OBS) for Prevention of Ovarian Cancer Be Incorporated Into Routine Care or Offered in the Context of a Clinical Trial?

Manchanda, R; Chandrasekaran, D; Saridogan, E; Burnell, M; Crawford, R; Brockbank, E; Kalsi, J; Jurkovic, D; Menon, U (2016-01)

Significant Decline in Galactomannan Signal during Storage of Clinical Serum Samples

Johnson, GL; Sarker, S-J; Hill, K; Tsitsikas, DA; Morin, A; Bustin, SA; Agrawal, SG (2013-07)

Sister Society Meeting on Global Education Development and Collaboration: Meeting Report.

Chuang, LT; Randall, TC; Denny, L; Johnston, CM; Schmeler, KM; Covens, AL; Cibula, D; Bookman, MA; Rawal, S; DePetrillo, D (2016-07)

OBJECTIVES: To identify common barriers to teaching and training and to identify strategies that would be useful in developing future training programs in gynecologic oncology in low- and middle- income countries. METHODS: ...