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In Situ Point Mutation Detection in FFPE Colorectal Cancers Using the BaseScope Assay.
(2020)
In situ mutation detection (ISMD) is a powerful tool for the characterization of tumor heterogeneity at cellular resolution while preserving tissue morphology and spatial context. The BaseScope assay is a novel approach ...
Detecting repeated cancer evolution in human tumours from multi-region sequencing data
(Nature Research, 2018-08-31)
Carcinogenesis is an evolutionary process driven by the accumulation of genomic aberrations. Recurrent sequences of genomic changes, both between and within patients, reflect repeated evolution that is valuable for ...