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dc.contributor.authorWald, DSen_US
dc.contributor.authorBestwick, JPen_US
dc.date.accessioned2018-03-13T13:52:35Z
dc.date.available2018-01-08en_US
dc.date.issued2018-03en_US
dc.date.submitted2018-01-10T13:20:36.890Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/34995
dc.description.abstractBackground Aortic stenosis is the most common cause of valvular heart disease with no means of prevention. Lowering serum levels of calcium or phosphate are potential preventive strategies but observational studies on the associations with aortic stenosis are inconsistent. Design and methods A case-control study was conducted in 132 individuals undergoing echocardiography (63 with aortic stenosis and 69 without) and the results combined with three other comparable studies (914 individuals overall) to provide a summary odds ratio of aortic stenosis for a 0.1 mmol/L increase (approximately one standard deviation) in calcium and phosphate respectively. The relationship between calcium and phosphate and the severity of aortic stenosis, according to peak trans-aortic velocity, was also examined in the case-control study using linear regression. Results Both calcium and phosphate were positively associated with aortic stenosis. The summary odds ratio for a 0.1 mmol/L increase in calcium was 1.79 (95% confidence interval 1.07-2.99), p = 0.027 and for phosphate it was 1.47 (1.08-2.01), p = 0.015. Peak trans-aortic velocity increased with phosphate levels, 9% (4%-14%) per 0.1 mmol/L, p = 0.001, but not with calcium, p = 0.089. Conclusions If the associations are causal and reversible, these results indicate that a small reduction in calcium or phosphate levels, within the physiological rage, would translate into a clinically significant reduction in the risk of aortic stenosis. Randomised trials of calcium and phosphate lowering therapies in aortic stenosis are needed.en_US
dc.format.extent551 - 556en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofEur J Prev Cardiolen_US
dc.subjectAortic stenosisen_US
dc.subjectcalciumen_US
dc.subjectphosphateen_US
dc.subjectpreventionen_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAortic Valveen_US
dc.subjectAortic Valve Stenosisen_US
dc.subjectBiomarkersen_US
dc.subjectCalcinosisen_US
dc.subjectCalciumen_US
dc.subjectEchocardiographyen_US
dc.subjectFemaleen_US
dc.subjectFollow-Up Studiesen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectPhosphatesen_US
dc.subjectRetrospective Studiesen_US
dc.titleAssociation between serum calcium, serum phosphate and aortic stenosis with implications for prevention.en_US
dc.typeArticle
dc.identifier.doi10.1177/2047487318756131en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29376752en_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume25en_US
qmul.funderPrevention of Aortic Stenosis (PAS) Pilot Trial::Medical Research Councilen_US


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