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Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque.
(Ivyspring International Publisher, 2020)
Overview: Cardiovascular disease remains a leading cause of death worldwide, with vulnerable plaque rupture the underlying cause of many heart attacks and strokes. Much research is focused on identifying an imaging biomarker ...
How spiders hunt heavy prey: the tangle web as a pulley and spider's lifting mechanics observed and quantified in the laboratory.
(2021-02)
The spiders of Theridiidae's family display a peculiar behaviour when they hunt extremely large prey. They lift the quarry, making it unable to escape, by attaching pre-tensioned silk threads to it. In this work, we analysed ...
Nanoscale Mapping Reveals Functional Differences in Ion Channels Populating the Membrane of Primary Cilia.
(2020-01-10)
BACKGROUND/AIMS: The primary cilium is a nanoscale membrane protrusion believed to act as a mechano-chemical sensor in a range of different cell types. Disruptions in its structure and signalling have been linked to a ...
Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology.
(2022-07-12)
Ex vivo preparations enable the study of many neurophysiological processes in isolation from the rest of the body while preserving local tissue structure. This work describes the preparation of rat sciatic nerves for ex ...
Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.
(2021-07-14)
The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based ...
Regulation of cardiomyocyte adhesion and mechanosignalling through distinct nanoscale behaviour of integrin ligands mimicking healthy or fibrotic extracellular matrix.
(2022-11-21)
The stiffness of the cardiovascular environment changes during ageing and in disease and contributes to disease incidence and progression. Changing collagen expression and cross-linking regulate the rigidity of the cardiac ...
Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.
(2021-04)
There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are ...