Epigenetic Regulation of the Protein Translation Machinery.
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There is a wealth of evidence from both epidemiological studies (Hales and Barker, 2001) and animal models (Tarry-Adkins and Ozanne, 2016) that environmental exposures during early mammalian development may alter developmental trajectories in a manner that results in altered disease susceptibility and stress responsiveness in later life. This phenomenology is termed ‘developmental programming.’ Developmental programming is of key interest because it has the potential to expand phenotypic diversity within a population in a manner that is not entirely accounted for by the underlying genetic diversity. Furthermore, there are many indicators that such factors may contribute to increased risk of human cardio-metabolic disease. Yet, despite convincing evidence at the phenotypic and epidemiological level, the molecular underpinnings of this phenomenon have remained enigmatic.
- Genomic Medicine