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Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
(Wiley, 2019-02-05)
Objective:
To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS).
Methods:
Linkage disequilibrium score regression and Mendelian randomization were applied in a large‐scale, ...
Predicting Diagnosis of Parkinson’s disease: A Risk Algorithm based on Primary Care presentations
(Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society, 2019-02-08)
BACKGROUND:
Diagnosis of Parkinson's disease (PD) is typically preceded by nonspecific presentations in primary care.
OBJECTIVES:
The objective of this study was to develop and validate a prediction model for diagnosis ...
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)
Background:
Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ...
Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
(Wiley, 2019-04-07)
Background:
Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the ...
Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time. A Systematic Review and Meta-analysis
(American Medical Association, 2019-05-28)