Browsing Centre for Preventative Neurology by Author "Blauwendraat, C"
Now showing items 1-13 of 13
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Differences in the Presentation and Progression of Parkinson's Disease by Sex
Iwaki, H; Blauwendraat, C; Leonard, HL; Makarious, MB; Kim, JJ; Liu, G; Maple-Grodem, J; Corvol, J-C; Pihlstrom, L; van Nimwegen, M (Wiley, 2020-10-01) -
Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease
Jerez, PA; Alcantud, JL; de los Reyes-Ramirez, L; Moore, A; Ruz, C; Montero, FV; Rodriguez-Losada, N; Saini, P; Gan-Or, Z; Alvarado, CX (2023) -
Gender Differences in the Prevalence of Parkinson's Disease
Zirra, A; Rao, SC; Bestwick, J; Rajalingam, R; Marras, C; Blauwendraat, C; Mata, I; Noyce, AJ (2023) -
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Blauwendraat, C; Reed, X; Krohn, L; Heilbron, K; Bandres-Ciga, S; Tan, M; Gibbs, JR; Hernandez, DG; Kumaran, R; Langston, R (2020-01-01)Parkinson's disease is a genetically complex disorder. Multiple genes have been shown to contribute to the risk of Parkinson's disease, and currently 90 independent risk variants have been identified by genome-wide association ... -
Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts
Iwaki, H; Blauwendraat, C; Leonard, HL; Liu, G; Maple-Grødem, J; Corvol, JC; Pihlstrøm, L; Van Nimwegen, M; Hutten, SJ; Nguyen, KDH (2019-08-01)Copyright © 2019 The Author(s). Objective To determine if any association between previously identified alleles that confer risk for Parkinson disease and variables measuring disease progression. Methods We evaluated the ... -
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Nalls, MA; Blauwendraat, C; Vallerga, CL; Heilbron, K; Bandres-Ciga, S; Chang, D; Tan, M; Kia, DA; Noyce, AJ; Xue, A (2019-12) -
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.
Blauwendraat, C; Kia, DA; Pihlstrøm, L; Gan-Or, Z; Lesage, S; Gibbs, JR; Ding, J; Alcalay, RN; Hassin-Baer, S; Pittman, AM (Elsevier, 2017-12-20)SNCA missense mutations are a rare cause of autosomal dominant Parkinson's disease (PD). To date, 6 missense mutations in SNCA have been nominated as causal. Here, we assess the frequency of these 6 mutations in public ... -
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
Blauwendraat, C; Iwaki, H; Makarious, MB; Bandres-Ciga, S; Leonard, H; Grenn, FP; Lake, J; Krohn, L; Tan, M; Kim, JJ (2021-04-26)OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Males are on average ~ 1.5 times more likely to develop PD compared to females with European ancestry. Over the years genome-wide association ... -
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data (vol 9, 33, 2023)
Leonard, HL; Murtadha, R; Martinez-Carrasco, A; Jama, A; Mueller-Nedebock, AC; Gil-Martinez, A-L; Illarionova, A; Moore, A; Bustos, BI; Jadhav, B (2023) -
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
Bandres-Ciga, S; Saez-Atienzar, S; Kim, JJ; Makarious, MB; Faghri, F; Diez-Fairen, M; Iwaki, H; Leonard, H; Botia, J; Ryten, M (2020-09) -
Multi-ancestry genome-wide association meta-analysis of Parkinson's disease.
Kim, JJ; Vitale, D; Otani, DV; Lian, MM; Heilbron, K; 23andMe Research Team; Iwaki, H; Lake, J; Solsberg, CW; Leonard, H (2024-01)Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale ... -
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank
Jacobs, BM; Belete, D; Bestwick, J; Blauwendraat, C; Bandres-Ciga, S; Heilbron, K; Dobson, R; Nalls, MA; Singleton, A; Hardy, J (BMJ, 2020-10) -
The Parkinson's Disease Mendelian Randomization Research Portal
Noyce, AJ; Bandres-Ciga, S; Kim, J; Heilbron, K; Kia, D; Hemani, G; Xue, A; Lawlor, DA; Smith, GD; Duran, R (2019-10-28)