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Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study.
(2020-01-01)
The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first ...
Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study.
(2020-03)
BACKGROUND: The Duke Activity Status Index (DASI) questionnaire might help incorporate self-reported functional capacity into preoperative risk assessment. Nonetheless, prognostically important thresholds in DASI scores ...
Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies.
(2020-02-09)
Diffuse alveolar hemorrhage is a severe respiratory complication of systemic lupus erythematosus. The illness develops over hours to a few days and is the systemic lupus erythematosus-associated syndrome with highest ...
Muscle wasting in the critically ill patient: how to minimise subsequent disability.
(Mark Allen Healthcare, 2020-04-02)
Muscle wasting in critically ill patients is the most common complication associated with critical care. It has significant effects on physical and psychological health, mortality and quality of life. It is most severe in ...
Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial.
(Elsevier Inc., 2020-04-02)
BACKGROUND: Acute skeletal muscle wasting in critical illness is associated with excess morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a result of the muscle-full effect, unlike ...
Prevention of postoperative pulmonary complications in the hypoxaemic patient - gathering the evidence for noninvasive respiratory support
(Lippincott, Williams & Wilkins, 2020-04-01)
Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study.
(2020-02-06)
PURPOSE: The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repair ...
Perioperative intravenous contrast administration and the incidence of acute kidney injury after major gastrointestinal surgery: prospective, multicentre cohort study.
(Wiley, 2020-02-05)
BACKGROUND: This study aimed to determine the impact of preoperative exposure to intravenous contrast for CT and the risk of developing postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal ...
ETHICAL: Ethnic Disparities In COVID-19 Admissions in east London
(Queen Mary University of London, Critical Care and Preoperative Medicine Research Group, 2020-05-18)
This study aims to assess whether there is a difference in age and sex adjusted outcomes in different ethnicities of patients with confirmed COVID 19 admitted to Barts Health. The study will test the hypothesis that there ...
Lung-kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup.
(2020-04)
BACKGROUND: Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) ...