Browsing Centre for Translational Medicine & Therapeutics by Issue Date
Now showing items 21-40 of 919
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
(Public Library of Science, 2009-04-02)The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing ... -
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A
(Wiley Online, 2010-07-21)Background and purpose: Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) is thought to underlie the vascular dysfunction, systemic hypotension and organ failure that characterize endotoxic shock. ...