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The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
(Frontiers Media, 2015-04-20)
CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting
tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of
CD44 standard and variant forms and ...
CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity.
(Ferrata Storti Foundation, 2020-07-02)
Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone ...