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    Cantú syndrome with coexisting familial pituitary adenoma. 
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    Cantú syndrome with coexisting familial pituitary adenoma.

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    Published version (1.204Mb)
    Volume
    59
    Pagination
    677 - 684
    DOI
    10.1007/s12020-017-1497-9
    Journal
    Endocrine
    Issue
    3
    Metadata
    Show full item record
    Abstract
    CONTEXT: Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION: We present a three-generation family with 5 affected members, with marked acromegaloid facies and prominent hypertrichosis, due to a novel missense variant in the ABCC9 gene. The proband, a 2-year-old girl, was referred due to marked hypertrichosis, noticed soon after birth, associated with coarsening of her facial appearance. Her endocrine assessment, including of the GH axis, was normal. The proband's father, paternal aunt, and half-sibling were referred to the Endocrine department for exclusion of acromegaly. Although the GH axis was normal in all, two subjects had clinically non-functioning pituitary macroadenomas, a feature which has not previously been associated with Cantú syndrome. CONCLUSIONS: Activating mutations in the ABCC9 and, less commonly, KCNJ8 genes-representing the two subunits of the ATP-sensitive potassium channel-have been linked with Cantú syndrome. Interestingly, minoxidil, a well-known ATP-sensitive potassium channel agonist, can cause a similar phenotype. There is no clear explanation why activating this channel would lead to acromegaloid features or hypertrichosis. This report raises awareness for this complex condition, especially for adult or pediatric endocrinologists who might see these patients referred for evaluation of acromegaloid features or hirsutism. The link between Cantú syndrome and pituitary adenomas is currently unclear.
    Authors
    Marques, P; Spencer, R; Morrison, PJ; Carr, IM; Dang, MN; Bonthron, DT; Hunter, S; Korbonits, M
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/32045
    Collections
    • Centre for Endocrinology [431]
    Language
    eng
    Licence information
    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
    Copyright statements
    © The Author(s) 2018
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