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dc.contributor.authorSvoren, E.M.
dc.identifier.citationSvoren, E.M. 2017. Genetic regulation of the host response to cardiac surgery and cardiopulmonary bypass. Queen Mary University of Londonen_US
dc.description.abstractThere is significant variation between individual patients in the magnitude and pattern of their systemic response to cardiac surgery. Poor outcomes in these patients have been associated with a dysfunctional host response. This thesis seeks to define such variability at the level of gene expression by sequential analysis of transcription before and after surgery for a low risk group of patients undergoing elective cardiac surgery and cardiopulmonary bypass (CPB) patients using expression microarray profiling. To that aim, we analysed sequential global gene expression patterns in circulating peripheral blood leukocytes. We also investigated the role of DNA sequence variation in modulating the observed changes in gene expression. This approach allowed us to identify important genetic modulators and novel biological pathways and gain new insights into the mechanisms that regulate the host response to surgery.en_US
dc.description.sponsorshipIntensive Care Society (Young Investigator Award) (£10,000) HCA International. Bench fees (£19,500) Collaborative Work University College of London (UCL). Genotyping cost (£20,000)en_US
dc.publisherQueen Mary University of Londonen_US
dc.rightsThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
dc.subjectcardiac surgeryen_US
dc.subjectcardiopulmonary bypassen_US
dc.subjectexpression microarray profilingen_US
dc.titleGenetic regulation of the host response to cardiac surgery and cardiopulmonary bypassen_US

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  • Theses [2768]
    Theses Awarded by Queen Mary University of London

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