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dc.contributor.authorBaker, A-Men_US
dc.contributor.authorHuang, Wen_US
dc.contributor.authorWang, X-MMen_US
dc.contributor.authorJansen, Men_US
dc.contributor.authorMa, X-Jen_US
dc.contributor.authorKim, Jen_US
dc.contributor.authorAnderson, CMen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorPan, Len_US
dc.contributor.authorSu, Nen_US
dc.contributor.authorLuo, Yen_US
dc.contributor.authorDomingo, Een_US
dc.contributor.authorHeide, Ten_US
dc.contributor.authorSottoriva, Aen_US
dc.contributor.authorLewis, Aen_US
dc.contributor.authorBeggs, ADen_US
dc.contributor.authorWright, NAen_US
dc.contributor.authorRodriguez-Justo, Men_US
dc.contributor.authorPark, Een_US
dc.contributor.authorTomlinson, Ien_US
dc.contributor.authorGraham, TAen_US
dc.date.accessioned2018-01-30T10:23:29Z
dc.date.available2017-11-17en_US
dc.date.issued2017-12-08en_US
dc.date.submitted2018-01-09T15:45:29.497Z
dc.identifier.issn2041-1723en_US
dc.identifier.otherARTN 1998en_US
dc.identifier.otherARTN 1998en_US
dc.identifier.otherARTN 1998en_US
dc.identifier.otherARTN 1998en_US
dc.identifier.otherARTN 1998en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/31830
dc.description.sponsorshipWe would like to thank George Elia and Emily Austen (BCI histopathology) for expert sectioning of FFPE material. This work was supported by Cancer Research UK (A14895, A.-M.B. and N.A.W.; A21870 A.L. and I.T.; A23923, A.D.B.; A22745, M.J.; A19771, T.A.G.) and the NIHR University College London Hospitals Biomedical Research Centre (MR-J). We also acknowledge the EU ERC EVOCAN and INSITUMUT projects (I.T.), the Wellcome Trust (102732/Z/13/Z, ADB; 202778/Z/16/Z, TAG; 202778/B/16/Z, A.S.) and core grant 090532/Z/09/Z to the Wellcome Trust Centre for Human Genetics from the Wellcome Trust (A.L., I.T.). A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer and by Cancer Research UK (C52506/A22909). A.S. and T.H. are supported by the Wellcome Trust grant to the Centre for Evolution and Cancer (105104/Z/14/Z). For tissue provision we acknowledge the UCL/UCLH Biobank for Health and Disease the FOCUS trial (Chief investigator Matt Seymour, University of Leeds and the MRC Clinical Trials Unit at UCL) and the S:CORT consortium (Phil Quirke and Susan Richman, sample curation and histopathology; Ultan MacDermott, Aikaterini Chatzipli and the Wellcome Trust Sanger institute for genetic sequencing on FOCUS trial samples within S:CORT; IT, ED, T.M. and A.B. for data analysis within S:CORT). S:CORT is an MRC and Cancer Research UK stratified medicine consortium for colorectal cancer (grant award no MR/M016587/1).en_US
dc.relation.ispartofNATURE COMMUNICATIONSen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.titleRobust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolutionen_US
dc.typeArticle
dc.rights.holder© The Author(s) 2017
dc.identifier.doi10.1038/s41467-017-02295-5en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000417467100008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.notesNo embargoen_US
pubs.publication-statusPublisheden_US
pubs.volume8en_US


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