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Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets.
(2018-08)
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with ...
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia.
(2018-10)
BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent ...
Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology.
(2018-05)
A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in particular gene sets. The dataset included a number of subjects ...
Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test.
(2018-01)
Polygenic risk scores obtained as a weighted sum of associated variants can be used to explore association in additional data sets and to assign risk scores to individuals. The methods used to derive polygenic risk scores ...
Negative Symptoms and Avoidance of Social Interaction: A Study of Non-Verbal Behaviour.
(2018)
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and ...
Association study of schizophrenia with variants in miR-137 binding sites.
(2018-07)
There is strong cumulative evidence for the involvement of miR-137 and its targets in the aetiology of schizophrenia. Here we test whether variants, especially rare variants, in miR-137 binding sites are associated with ...
Correspondence between negative symptoms and potential sources of secondary negative symptoms over time.
(2018-09)
There has been a debate in the literature about the distinction between primary and secondary negative symptoms of schizophrenia. Our aim was to study the associations between negative symptoms and potential sources of ...
Clinicians have several therapeutic relationships and patients only one: The effect on their assessments of relationships.
(2018-12)
OBJECTIVES: Little attention has been given to the common assessment problem that clinicians assess outcomes of several patients and may rate them in comparison to one another, whereas patients assess only their own outcomes ...
Age at first birth in women is genetically associated with increased risk of schizophrenia.
(2018-07-05)
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent ...