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Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
(2017-10)
Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ...
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
(Springer Nature, 2019-03-25)
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex ...