Now showing items 1-10 of 29
The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer.
The relationship between the number of cigarettes smoked per day and the incidence of lung cancer is linear but, from the multistage model of carcinogenesis, it should be quadratic (upwards curving). We investigated this ...
Specifying a Gold Standard for the Validation of Fetal Fraction Estimation in Prenatal Screening.
BACKGROUND: An estimate of fetal fraction (FF) is needed for DNA-based screening for trisomy 21 and other aneuploidies, but there is no gold standard to validate FF measurement methods. We specify a gold standard and use ...
Prenatal maternal plasma DNA screening for cystic fibrosis: A computer modelling study of screening performance.
Background: Prenatal cystic fibrosis (CF) screening is currently based on determining the carrier status of both parents. We propose a new method based only on the analysis of DNA in maternal plasma. Methods: The method ...