Now showing items 1-6 of 6
Specifying a Gold Standard for the Validation of Fetal Fraction Estimation in Prenatal Screening.
BACKGROUND: An estimate of fetal fraction (FF) is needed for DNA-based screening for trisomy 21 and other aneuploidies, but there is no gold standard to validate FF measurement methods. We specify a gold standard and use ...
Prenatal reflex DNA screening for trisomies 21, 18, and 13.
PURPOSE: The purpose of the study was to determine the screening performance of prenatal reflex DNA screening for trisomies 21 (T21), 18 (T18), and 13 (T13) as part of a routine service at five hospitals. METHODS: Women ...
Response to Walker.
Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies.
The aims of this study were to determine whether assumptions used in prenatal screening for Down syndrome in twin pregnancies are valid and derive estimates of risk and screening performance in twin pregnancies using ...
Serum marker truncation limits in first trimester antenatal screening for trisomy 18.
OBJECTIVE: To assess whether the accuracy of risk estimation in antenatal screening for trisomy 18 using the Combined test can be improved by revising the truncation limits of two serum markers. METHODS: In an audit of ...
Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate.
The neural tube defects anencephaly and spina bifida are two of the most common serious congenital malformations. Most cases can be prevented by consuming sufficient folic acid immediately before pregnancy and in early ...