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Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets.
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with ...
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia.
BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent ...
Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ...