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Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets.
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with ...
Community treatment orders in England: review of usage from national data.
Aims and methodCommunity treatment orders (CTOs) have been in used in England and Wales since November 2008; however, their effectiveness has been debated widely, as has the question of which methodology is appropriate to ...
Mini-review: Update on the genetics of schizophrenia.
A number of important findings have recently emerged relevant to identifying genetic risk factors for schizophrenia. Findings using common variants point towards gene sets of interest and also demonstrate an overlap with ...
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia.
BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent ...
A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score.
Previously described methods of analysis allow variants in a gene to be weighted more highly according to rarity and/or predicted function and then for the variant contributions to be summed into a gene-wise risk score, ...
Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ...