Browsing Wolfson Institute of Preventive Medicine by Title
Now showing items 2386-2405 of 2451
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Web-Based Measure of Life Events Using Computerized Life Events and Assessment Record (CLEAR): Preliminary Cross-Sectional Study of Reliability, Validity, and Association With Depression.
(JMIR Publications, 2019-01-08)BACKGROUND: Given the criticisms of life event checklists and the costs associated with interviews, life event research requires a sophisticated but easy-to-use measure for research and clinical practice. Therefore, the ... -
Weekly COVID-19 testing with household quarantine and contact tracing is feasible and would probably end the epidemic
(Royal Society, 2020-06-24) -
Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology.
(2018-05)A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in particular gene sets. The dataset included a number of subjects ... -
Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways.
(2020-02-05)Previous studies have implicated common and rare genetic variants as risk factors for late-onset Alzheimer's disease (LOAD). Here, weighted burden analysis was applied to over 10,000 exome-sequenced subjects from the ... -
A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score.
(2019-01)Previously described methods of analysis allow variants in a gene to be weighted more highly according to rarity and/or predicted function and then for the variant contributions to be summed into a gene-wise risk score, ... -
What cervical screening is appropriate for women who have been vaccinated against high risk HPV? A simulation study.
(2018-02-15)Women vaccinated against HPV16/18 are approaching the age for cervical screening; however, an updated screening algorithm has not been agreed. We use a microsimulation model calibrated to real published data to determine ...