Search
Now showing items 1-10 of 12
Efficiency and prioritization of inference-based credit assignment.
(Elsevier, 2021-07-12)
Organisms adapt to their environments by learning to approach states that predict rewards and avoid states associated with punishments. Knowledge about the affective value of states often relies on credit assignment (CA), ...
Human complex exploration strategies are enriched by noradrenaline-modulated heuristics.
(eLife, 2021-01-04)
An exploration-exploitation trade-off, the arbitration between sampling a lesser-known against a known rich option, is thought to be solved using computationally demanding exploration algorithms. Given known limitations ...
Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference.
(eLife, 2021-12-09)
Dopamine is implicated in representing model-free (MF) reward prediction errors a as well as influencing model-based (MB) credit assignment and choice. Putative cooperative interactions between MB and MF systems include a ...
Feasibility and safety of radical prostatectomy for oligo-metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo-Metastases to the bone (TRoMbone) trial.
(2022-07)
OBJECTIVES: To test the feasibility of randomisation to radical prostatectomy (RP) plus pelvic lymphadenectomy in addition to standard-of-care (SOC) systemic therapy in men with newly diagnosed oligo-metastatic prostate ...
Comparative Effectiveness Analyses of Salvage Prostatectomy and Salvage Radiotherapy Outcomes Following Focal or Whole-Gland Ablative Therapy (High-Intensity Focused Ultrasound, Cryotherapy or Electroporation) for Localised Prostate Cancer.
(2022-01)
AIMS: Ablative therapy, such as focal therapy, cryotherapy or electroporation, aims to treat clinically significant prostate cancer with reduced treatment-related toxicity. Up to a third of patients may require further ...
Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity.
(2021-06-09)
Control of protein intake is essential for numerous biological processes as several amino acids cannot be synthesized de novo, however, its neurobiological substrates are still poorly understood. In the present study, we ...
Harm and Addiction Perceptions of the JUUL E-Cigarette Among Adolescents.
(2020-04-21)
INTRODUCTION: This study assessed adolescents' harm and addiction perceptions of the highest-selling brand-JUUL-of the most commonly used tobacco product-electronic cigarettes (e-cigarettes)-among adolescents in the United ...
Exploring three levels of interoception in people with functional motor disorders.
(2021-05)
INTRODUCTION: A three-level model of interoception has recently been defined. We aim to study the interoceptive processing in individuals with functional motor disorder (FMD). METHODS: Twenty-two patients with FMD were ...
Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants
(eLife Sciences Publications, 2021-03-05)
Determining the molecular properties of neurons is essential to understand their development, function and evolution. Using Targeted DamID (TaDa), we characterize RNA polymerase II occupancy and chromatin accessibility in ...
The hippocampus and orbitofrontal cortex jointly represent task structure during memory-guided decision making
(Cell Press, 2021-11-30)
The hippocampus, well known for its role in episodic memory, might also be an important brain region for extracting structure from our experiences in order to guide future decisions. Recent evidence in rodents suggests ...