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The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.
(2015)
Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth ...
Charting the host adaptation of influenza viruses.
(2011-06)
Four influenza pandemics have struck the human population during the last 100 years causing substantial morbidity and mortality. The pandemics were caused by the introduction of a new virus into the human population from ...
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.
(2012-03)
Estimation of the distribution of selection coefficients of mutations is a long-standing issue in molecular evolution. In addition to population-based methods, the distribution can be estimated from DNA sequence data by ...
The CogBIAS longitudinal study protocol: cognitive and genetic factors influencing psychological functioning in adolescence.
(2017-12-29)
BACKGROUND: Optimal psychological development is dependent upon a complex interplay between individual and situational factors. Investigating the development of these factors in adolescence will help to improve understanding ...
Integrating evolution into ecological modelling: accommodating phenotypic changes in agent based models.
(2013)
Evolutionary change is a characteristic of living organisms and forms one of the ways in which species adapt to changed conditions. However, most ecological models do not incorporate this ubiquitous phenomenon. We have ...
Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.
(2013)
Parkinson's disease (PD) is pathologically characterized by the presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra. These intracellular inclusions are largely composed of misfolded α-synuclein ...
Having a lot of a good thing: multiple important group memberships as a source of self-esteem.
(2015)
Membership in important social groups can promote a positive identity. We propose and test an identity resource model in which personal self-esteem is boosted by membership in additional important social groups. Belonging ...
Bayesian estimation of nonsynonymous/synonymous rate ratios for pairwise sequence comparisons.
(2014-07)
The nonsynonymous/synonymous rate ratio (ω = d(N)/d(S)) is an important measure of the mode and strength of natural selection acting on nonsynonymous mutations in protein-coding genes. The simplest such analysis is the ...
Arts-based interventions in healthcare education.
(2018-03)
Healthcare education institutions are increasingly including arts-based interventions in their programmes. We analysed 62 studies of arts-based interventions to understand how these interventions may be beneficial, and why ...