Browsing School of Biological and Chemical Sciences by Title
Now showing items 2139-2158 of 3203
-
P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma.
(2023-01-31)Hotspot mutations in the NRAS gene are causative genetic events associated with the development of melanoma. Currently, there are no FDA-approved drugs directly targeting NRAS mutations. Previously, we showed that p38 acts ... -
Paleogenomics of Animal Domestication
(2018-10-11)Starting with dogs, over 15,000 years ago, the domestication of animals has been central in the development of modern societies. Because of its importance for a range of disciplines—including archaeology, biology, and the ... -
Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to β2,2 -Amino Acids.
(2018-04-03)We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β2,2 -amino acids ... -
Parallel Evolution in the Integration of a Co-obligate Aphid Symbiosis
(Elsevier BV, 2020-04)Dependence on multiple nutrient- provisioning symbionts has evolved numerous times in insects. Monnin et al. provide evidence from the symbionts of aphids that these dependencies evolve in a predictable manner. The repeated ... -
Parallel independent losses of g-type lysozyme genes in hairless aquatic mammals.
(Oxford University Press, 2021-08-27)Lysozyme enzymes provide classic examples of molecular adaptation and parallel evolution, however, nearly all insights to date come from c-type lysozymes. G-type lysozymes occur in diverse vertebrates, with multiple ... -
Parallel Mechanisms for Visual Search in Zebrafish
(2014-10-29) -
Parental transposable element loads influence their dynamics in young Nicotiana hybrids and allotetraploids.
(Wiley on behalf of New Phytologist Trust, 2019-02)The genomic shock hypothesis suggests that allopolyploidy is associated with genome changes driven by transposable elements, as a response to imbalances between parental insertion loads. To explore this hypothesis, we ... -
Pathfinder: A gamified measure to integrate general cognitive ability into the biological, medical, and behavioural sciences
(Springer Nature [academic journals on nature.com], 2021-10-01)Genome-wide association (GWA) studies have uncovered DNA variants associated with individual differences in general cognitive ability ( g ), but these are far from capturing heritability estimates obtained from twin studies. ...