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dc.contributor.authorREYNOLDS, LAen_US
dc.contributor.authorTansey, EMen_US
dc.contributor.editorREYNOLDS, LAen_US
dc.contributor.editorTANSEY, EMen_US
dc.date.accessioned2012-10-09T08:26:11Z
dc.date.issued2005-12-20en_US
dc.identifier.isbn0854841024en_US
dc.identifier.isbn9780854841028en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/2759
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005.©The Trustee of the Wellcome Trust, London, 2005.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/en_US
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.en_US
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.en_US
dc.descriptionAnnotated and edited transcript of a Witness Seminar held on 15 June 2004. Introduction by Barbara Stocking, Oxfam.en_US
dc.description.abstractIn 1959 the New Zealand obstetrician Graham (Mont) Liggins began investigating mechanisms that triggered premature labour. Supported by the Wellcome Trust, he examined the effects of hormones on labour in sheep, and demonstrated coincidentally that in utero corticosteroids accelerated fetal lung maturation. A randomized controlled trial (RCT) of prenatal corticosteroids in humans by Liggins and pediatrician Ross Howie, showed a reduction of respiratory distress syndrome in preterm babies. This Witness Seminar, chaired by the late Dr Edmund Hey, discussed the influence of Liggins' and Howie's 1972 paper announcing these results, and subsequent work by Avery and Kotas on induction of pulmonary surfactant in lambs. Other subjects included Crowley's 1981 systematic review of four RCTs; the low uptake of corticosteroids in practice until the Royal College of Obstetricians and Gynaecologists issued usage guidelines in 1992; trials to determine optimum drug, dose and number of courses; potential adverse effects; and cost-benefit analysis. Participants included the late Dr Mel Avery, Sir Iain Chalmers, Dr Patricia Crowley, the late Professor Harold Gamsu, Professor Jane Harding, Professor Richard Lilford, Professor Miranda Mugford, Professor Ann Oakley, Professor Dafydd Walters and Mr John Williams. Appendices from Liggins and Howie; Liggins' Wellcome Trust grant; and the protocol of the 1975 UK trial of betamethasone, complete the volume. Reynolds L A, Tansey E M. (eds) (2005) Prenatal corticosteroids for reducing morbidity and mortality after preterm birth, Wellcome Witnesses to Twentieth Century Medicine, volume 25. London: The Wellcome Trust Centre for the History of Medicine at UCL.en_US
dc.description.sponsorshipThe Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183.en_US
dc.format.extenti - 150 (172)en_US
dc.format.mediumpaper and open access
dc.format.mediumpaper and open access
dc.format.mediumpaper and open access
dc.format.mediumpaper and open access
dc.format.mediumpaper and open accessen_US
dc.format.mediumpaper and open accessen_US
dc.format.mediumpaper and open accessen_US
dc.language.isoenen_US
dc.publisherWellcome Trust Centre for the History of Medicine at UCLen_US
dc.relation.ispartofWellcome Witnesses to Twentieth Century Medicineen_US
dc.subjectrespiratory distress syndromeen_US
dc.subjectsurfactanten_US
dc.subjectglucocorticoidsen_US
dc.subject1972 RCT and follow upen_US
dc.subjectmeta-analysisen_US
dc.subjectcost-benefit analysisen_US
dc.subjecthealth economicsen_US
dc.titlePrenatal Corticosteroids for Reducing Morbidity and mortality after Preterm Birthen_US
dc.typeBook
pubs.notesNot knownen_US
pubs.place-of-publicationLONDONen_US
pubs.publication-statusPublisheden_US
pubs.volume25en_US


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