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dc.contributor.authorNizam, Nen_US
dc.contributor.authorEren, Gen_US
dc.contributor.authorAkcalı, Aen_US
dc.contributor.authorDonos, Nen_US
dc.date.accessioned2017-10-03T13:51:47Z
dc.date.available2017-07-19en_US
dc.date.issued2018-01en_US
dc.date.submitted2017-09-20T11:00:19.408Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/26523
dc.description.abstractOBJECTIVES: To evaluate the effect of leukocyte and platelet-rich fibrin (L-PRF) in combination with deproteinized bovine bone mineral (DBBM) on bone regeneration in maxillary sinus augmentation. MATERIAL AND METHODS: Thirteen patients (nine males and four females, mean age ± SD; 49.92 ± 10.37) were enrolled to the study. 26 maxillary sinus augmentation procedures were randomly performed using DBBM and L-PRF mixture (test) or DBBM alone (control) in a split-mouth design. The same surgical procedures were performed in both groups, and bone biopsies were harvested from the implant sites 6 months postoperatively for histological and histomorphometric evaluations as the primary outcome of the study. Implants were placed and then loaded in the augmented sites after 6 months. The secondary outcomes included clinical and radiographic data and were obtained pre- and postoperatively. RESULTS: There was no qualitative difference in histological analyses among the groups. In all samples, a newly formed bone was in direct contact with the residual material. The percentages of newly formed bone (test; 21.38 ± 8.78% and control; 21.25 ± 5.59%), residual bone graft (test; 25.95 ± 9.54% and control; 32.79 ± 5.89%), bone graft in contact with the newly formed bone (test; 47.33 ± 12.33% and control; 54.04 ± 8.36%), and soft tissue (test; 52.67 ± 12.53% and control; 45.96 ± 8.36%) were similar among the groups (p < .05). Similar radiographic bone height in the augmented area was observed, and implant survival rate was 100% for both groups. CONCLUSIONS: Both techniques were effective for maxillary sinus augmentation, and after 6 months of healing, the addition of L-PRF in DBBM did not improve the amount of regenerated bone or the amount of the graft integrated into the newly formed bone under histological and histomorphometric evaluation.en_US
dc.format.extent67 - 75en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofClin Oral Implants Resen_US
dc.rights"This is the peer reviewed version of the following article: Nizam N, Eren G, Akcalı A, Donos N. Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study. Clin Oral Impl Res. 2017;00:1–9. DOI: 10.1111/clr.13044 which has been published in final form at https://doi.org/10.1111/clr.13044 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
dc.subjectL-PRFen_US
dc.subjectbone graftsen_US
dc.subjectbone regenerationen_US
dc.subjectmaxillary sinus augmentationen_US
dc.subjectAdulten_US
dc.subjectAnimalsen_US
dc.subjectBone Regenerationen_US
dc.subjectBone Substitutesen_US
dc.subjectCattleen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLeukocytesen_US
dc.subjectMaleen_US
dc.subjectMaxillary Sinusen_US
dc.subjectMiddle Ageden_US
dc.subjectMineralsen_US
dc.subjectPlatelet-Rich Fibrinen_US
dc.subjectSinus Floor Augmentationen_US
dc.titleMaxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study.en_US
dc.typeArticle
dc.identifier.doi10.1111/clr.13044en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28786494en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume29en_US
dcterms.dateAccepted2017-07-19en_US


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