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dc.contributor.authorTreibel, TAen_US
dc.contributor.authorRossi, Aen_US
dc.contributor.authorPugliese, Fen_US
dc.contributor.authorDavies, LCen_US
dc.date.accessioned2017-10-02T08:29:49Z
dc.date.available2017-07-20en_US
dc.date.issued2017-09en_US
dc.date.submitted2017-09-28T15:26:27.654Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/26063
dc.description.abstractINTRODUCTION: Rapid technological advances in computed tomography (CT) have allowed CT coronary angiography (CTCA) to be delivered at low radiation dose and high diagnostic accuracy. Due to its high negative predictive value for coronary artery disease, it has become a gatekeeper for the assessment of patients with chest pain of recent onset. Second line functional assessment of a detected coronary stenosis relies mostly on other imaging modalities. Functional assessment of coronary artery disease by CT is therefore an attractive addition to CTCA. Areas covered: This review will discuss the current evidence base and future development for CT perfusion imaging. Furthermore, this review will discuss CT-derived fractional flow reserve and CT coronary plaque characteristics as alternative approaches for functional evaluation of coronary artery disease. Finally, combining coronary anatomy and functional assessment of coronary flow with myocardial tissue characterization by CT may be attractive allowing triple assessment by CT. Expert commentary: The combined use of CTCA and functional assessment of coronary artery stenosis by CT perfusion or CT-derived fractional flow reserve is an attractive diagnostic pathway that requires further evaluation.en_US
dc.description.sponsorshipThis work forms part of the translation research portfolio of the NIHR Cardiovascular Biomedical Research Unit at Barts, which is supported and funded by the NIHR.en_US
dc.format.extent657 - 665en_US
dc.languageengen_US
dc.relation.ispartofExpert Rev Cardiovasc Theren_US
dc.rightsThis is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Cardiovascular Therapy on 25 Jul 2017, available online: http://www.tandfonline.com/10.1080/14779072.2017.1359087
dc.subjectCT FFRen_US
dc.subjectCardiac computed tomographyen_US
dc.subjectmyocardial perfusion imagingen_US
dc.subjectComputed Tomography Angiographyen_US
dc.subjectCoronary Angiographyen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectCoronary Stenosisen_US
dc.subjectFractional Flow Reserve, Myocardialen_US
dc.subjectHumansen_US
dc.subjectPlaque, Atheroscleroticen_US
dc.subjectPredictive Value of Testsen_US
dc.subjectTomography, X-Ray Computeden_US
dc.titleFunctional assessment of coronary artery disease by cardiac computed tomography.en_US
dc.typeArticle
dc.rights.holderCopyright © 2017 Taylor & Francis Group
dc.identifier.doi10.1080/14779072.2017.1359087en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28728443en_US
pubs.issue9en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume15en_US


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