Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells (PICs) Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
JACC: Basic to Translational Science
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Skeletal muscle-derived PW1 pos/Pax7neg interstitial cells (PICs) express and secrete a multitude of pro-regenerative growth factors and cytokines. Utilizing a porcine pre-clinical skeletal muscle injury model, delivery of allogeneic pPICs significantly improved and accelerated myofiber regeneration and neocapillarization, compared to saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply and readily available regenerative therapeutic strategy.
AuthorsLEWIS, F; Cottle, BJ; Shone, V; Marazzi, G; Sassoon, D; Tseng, CCS; Dankers, PYW; Chamuleau, SAJ; Nadal-Ginard, B; Ellison-Hughes, GM
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