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dc.contributor.authorFurmanski, ALen_US
dc.contributor.authorO'Shaughnessy, RFLen_US
dc.contributor.authorSaldana, JIen_US
dc.contributor.authorBlundell, MPen_US
dc.contributor.authorThrasher, AJen_US
dc.contributor.authorSebire, NJen_US
dc.contributor.authorDavies, EGen_US
dc.contributor.authorCrompton, Ten_US
dc.date.accessioned2017-08-25T11:17:31Z
dc.date.issued2013-05en_US
dc.date.submitted2017-07-21T09:58:56.404Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/25472
dc.description.abstractHere we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell immunodeficiency in congenital athymia, but is associated with autoimmunity. We established a mouse model of thymus transplantation by subcutaneously implanting human thymus tissue into athymic C57BL/6 nude mice. These xenografts supported mouse T-cell development. Surprisingly, we did not detect multiorgan autoimmune disease. However, in all transplanted mice, we noted a striking depigmentation and loss of hair follicles. Transfer of T cells from transplanted nudes to syngeneic black-coated RAG(-/-) recipients caused progressive, persistent coat-hair whitening, which preceded patchy hair loss in depigmented areas. Further transfer experiments revealed that these phenomena could be induced by CD4+ T cells alone. Immunofluorescent analysis suggested that Trp2+ melanocyte-lineage cells were decreased in depigmented hair follicles, and pathogenic T cells upregulated activation markers when exposed to C57BL/6 melanocytes in vitro, suggesting that these T cells are not tolerant to self-melanocyte antigens. Our data raise interesting questions about the mechanisms underlying tissue-specific tolerance to skin antigens.en_US
dc.format.extent1221 - 1230en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofJ Invest Dermatolen_US
dc.rightsCC-BY-NC-ND
dc.subjectAdoptive Transferen_US
dc.subjectAlopeciaen_US
dc.subjectAnimalsen_US
dc.subjectCD4-Positive T-Lymphocytesen_US
dc.subjectCell Proliferationen_US
dc.subjectDisease Models, Animalen_US
dc.subjectHair Coloren_US
dc.subjectHair Follicleen_US
dc.subjectHomeodomain Proteinsen_US
dc.subjectHumansen_US
dc.subjectIn Vitro Techniquesen_US
dc.subjectMelanocytesen_US
dc.subjectMiceen_US
dc.subjectMice, Inbred C57BLen_US
dc.subjectMice, Knockouten_US
dc.subjectMice, Nudeen_US
dc.subjectPigmentationen_US
dc.subjectThymus Glanden_US
dc.subjectTransplantation, Heterologousen_US
dc.subjectUp-Regulationen_US
dc.titleT-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.en_US
dc.typeArticle
dc.rights.holder© 2013 The Society for Investigative Dermatology, Inc.
dc.identifier.doi10.1038/jid.2012.492en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23303453en_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume133en_US


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