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dc.contributor.authorTilwani, RKen_US
dc.contributor.authorBader, DLen_US
dc.contributor.authorChowdhury, TTen_US
dc.date.accessioned2017-08-08T09:04:31Z
dc.date.available2011-12-28en_US
dc.date.issued2012-01-05en_US
dc.date.submitted2017-07-21T16:16:28.684Z
dc.identifier.issn2079-4983en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/25109
dc.description.abstractBiomechanical signals play an important role in normal disc metabolism and pathology. For instance, nucleus pulposus (NP) cells will regulate metabolic activities and maintain a balance between the anabolic and catabolic cascades. The former involves factors such as transforming growth factor-β (TGFβ) and mechanical stimuli, both of which are known to regulate matrix production through autocrine and paracrine mechanisms. The present study examined the combined effect of TGFβ and mechanical loading on anabolic activities in NP cells cultured in agarose constructs. Stimulation with TGFβ and dynamic compression reduced nitrite release and increased matrix synthesis and gene expression of aggrecan and collagen type II. The findings from this work has the potential for developing regenerative treatment strategies which could either slow down or stop the degenerative process and/or promote healing mechanisms in the intervertebral disc.en_US
dc.description.sponsorshipThe work was supported by the AO Research Fund of the AO Foundation (S-09-83C).en_US
dc.format.extent23 - 36en_US
dc.languageengen_US
dc.relation.ispartofJ Funct Biomateren_US
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
dc.titleBiomechanical Conditioning Enhanced Matrix Synthesis in Nucleus Pulposus Cells Cultured in Agarose Constructs with TGFβ.en_US
dc.typeArticle
dc.rights.holder© 2012 by the authors; licensee MDPI, Basel, Switzerland
dc.identifier.doi10.3390/jfb3010023en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24956513en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume3en_US
dcterms.dateAccepted2011-12-28en_US
qmul.funderBeneficial effect of CNP and mechanical loading in human cartilage::AO Foundationen_US


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