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dc.contributor.authorPanagiotopoulou, M
dc.contributor.authorSalinas, Y
dc.contributor.authorBeyazit, S
dc.contributor.authorKunath, S
dc.contributor.authorDuma, L
dc.contributor.authorProst, E
dc.contributor.authorMayes, AG
dc.contributor.authorResmini, M
dc.contributor.authorTse Sum Bui, B
dc.contributor.authorHaupt, K
dc.date.accessioned2017-08-04T15:10:16Z
dc.date.available2017-08-04T15:10:16Z
dc.date.issued2016-05-30
dc.date.submitted2017-08-01T12:41:13.222Z
dc.identifier.citationM. Panagiotopoulou, Y. Salinas, S. Beyazit, S. Kunath, L. Duma, E. Prost, A. G. Mayes, M. Resmini, B. Tse Sum Bui, K. Haupt, Angew. Chem. Int. Ed. 2016, 55, 8244.en_US
dc.identifier.issn1433-7851
dc.identifier.other10.1002/anie.201601122
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/25063
dc.description.abstractAdvanced tools for cell imaging are of great interest for the detection, localization, and quantification of molecular biomarkers of cancer or infection. We describe a novel photopolymerization method to coat quantum dots (QDs) with polymer shells, in particular, molecularly imprinted polymers (MIPs), by using the visible light emitted from QDs excited by UV light. Fluorescent core-shell particles specifically recognizing glucuronic acid (GlcA) or N-acetylneuraminic acid (NANA) were prepared. Simultaneous multiplexed labeling of human keratinocytes with green QDs conjugated with MIP-GlcA and red QDs conjugated with MIP-NANA was demonstrated by fluorescence imaging. The specificity of binding was verified with a non-imprinted control polymer and by enzymatic cleavage of the terminal GlcA and NANA moieties. The coating strategy is potentially a generic method for the functionalization of QDs to address a much wider range of biocompatibility and biorecognition issues.en_US
dc.description.sponsorshipThis research was supported by the European RegionalDevelopment Fund, the Region of Picardy (CPER 2007–2013), and the European Commission (FP7 Marie CurieActions,projects NANODRUG,MCITN-2011-289554, andSAMOSS,PITN-2013–607590).en_US
dc.format.extent8244 - 8248
dc.languageeng
dc.language.isoenen_US
dc.publisherWiley Onlineen_US
dc.relation.ispartofAngew Chem Int Ed Engl
dc.rights"This is the peer reviewed version of the following article: M. Panagiotopoulou, Y. Salinas, S. Beyazit, S. Kunath, L. Duma, E. Prost, A. G. Mayes, M. Resmini, B. Tse Sum Bui, K. Haupt, Angew. Chem. Int. Ed. 2016, 55, 8244.. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subjectbioimagingen_US
dc.subjectmolecularly imprinted polymersen_US
dc.subjectnanocompositesen_US
dc.subjectquantum dotsen_US
dc.subjectsynthetic receptorsen_US
dc.titleMolecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging.en_US
dc.typeArticleen_US
dc.rights.holderÓ2016 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim
dc.identifier.doi10.1002/anie.201601122
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27238424
pubs.issue29
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Biological and Chemical Sciences - Staff
pubs.publication-statusPublished
pubs.volume55


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