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dc.contributor.authorKhanji, Mohmed Yunus
dc.date.accessioned2017-07-05T09:57:49Z
dc.date.available2017-07-05T09:57:49Z
dc.date.issued2017-04-01
dc.date.submitted2017-07-05T10:16:22.243Z
dc.identifier.citationKhanji, M.Y. 2017. Clinical Effectiveness of Tailored E2coaching in Reducing Cardiovascular Risk Assessed Using Cardiovascular Imaging and Functional Assessment 2 A Primary Prevention Trial in Moderate to High Risk Individuals. Queen Mary University of Londonen_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/24707
dc.descriptionPhDen_US
dc.description.abstractCardiovascular disease remains one of the leading causes of mortality globally. Innovative techniques are required to tackle its anticipated rise due to rising obesity, diabetes and an ageing population. Personalised electronic coaching (eb coaching) using the Internet and emails may help motivate healthier living and be of clinical benefit in complementing current programmes for cardiovascular risk reduction. I investigated whether personalised ebcoaching on top of SOC was more clinically effective than SOC alone, in reducing cardiovascular risk in asymptomatic individuals with high cardiovascular risk. I lead a randomised controlled trial of 402 participants using robust surrogate markers to identify change over 6 months. I assessed the feasibility of using cardiovascular magnetic resonance surrogate markers to guide their use in future studies of lifestyle interventions. I performed systematic reviews to identify 1) similarities and differences among leading primary prevention guidelines that address cardiovascular screening and risk assessment and 2) guideline recommendations on lifestyle advice and interventions to identify how ebcoaching could be used and what advice to incorporate in ebcoaching platforms. I found modest but statistically significant improvements in both ebcoaching and SOC groups to a similar level. Personalised ebcoaching did not show additional benefit in a highbrisk primary prevention cohort. It is feasible to use cardiovascular surrogate markers derived from cardiovascular magnetic resonance in lifestyle interventions studies. However, further studies correlating change in these markers with longbterm outcomes are required. Considerable discrepancies exist in the guidelines on risk on cardiovascular screening and risk assessment, with no consensus on optimum screening strategies or classification of high risk thus affecting treatment threshold. Guidelines did highlight the importance of lifestyle interventions in primary prevention and generally provided similar advice. Ebcoaching should not be incorporated into current prevention programmes for high risk populations unless the tools are improved and effectiveness is proven.en_US
dc.language.isoenen_US
dc.publisherQueen Mary University of Londonen_US
dc.rightsThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
dc.subjectCardiovascular Imagingen_US
dc.subjectCardiovascular Risk Assessmenten_US
dc.subjectCardiovascular diseaseen_US
dc.titleClinical Effectiveness of Tailored E2coaching in Reducing Cardiovascular Risk Assessed Using Cardiovascular Imaging and Functional Assessment 2 A Primary Prevention Trial in Moderate to High Risk Individualsen_US
dc.typeThesisen_US


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