The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis.
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BACKGROUND: The aim of this individual participant data meta-analysis (IPDMA) is to evaluate the effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early childhood outcomes at ages 3-5 years. METHODS/DESIGN: We will build on the established International Weight Management in Pregnancy (i-WIP) IPD Collaborative Network, having identified researchers who have conducted randomised dietary and lifestyle interventions among pregnant women who are overweight or obese, and where ongoing childhood follow-up of participants has been or is being undertaken. The primary maternal outcome is a diagnosis of maternal metabolic syndrome. The primary childhood outcome is BMI above 90%. We have identified 7 relevant trials, involving 5425 women who were overweight or obese during pregnancy, with approximately 3544 women and children with follow-up assessments available for inclusion in the meta-analysis. DISCUSSION: The proposed IPDMA provides an opportunity to evaluate the effect of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early childhood health outcomes, including risk of obesity. This knowledge is essential to effectively translate research findings into clinical practice and public health policy. SYSTEMATIC REVIEW REGISTRATION: This IPD has been prospectively registered (PROSPERO), ID number CRD42016047165 .
AuthorsDodd, JM; Grivell, RM; Louise, J; Deussen, AR; Giles, L; Mol, BW; Vinter, C; Tanvig, M; Jensen, DM; Bogaerts, A; Devlieger, R; Luoto, R; McAuliffe, F; Renault, K; Carlsen, E; Geiker, N; Poston, L; Briley, A; Thangaratinam, S; Rogozinska, E; Owens, JA
- Population Health