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dc.contributor.editorJones EM
dc.contributor.editorTansey EM
dc.date.accessioned2017-06-08T13:26:18Z
dc.date.available2017-06-08T13:26:18Z
dc.date.issued2013
dc.date.submitted2017-06-08T11:38:25.352Z
dc.identifier.isbn9780902238855
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/23667
dc.description.abstractColorectal, or bowel, cancers are the third most commonly-diagnosed type of cancers. Chaired by Professor Peter Harper, this Witness Seminar examines breakthroughs in medical research that have determined the genetic basis of many such cancers. The introduction explains, in particular, the role of the UK’s Cancer Family Study Group, founded in 1984, whilst during the seminar several participants recall that period as one of scepticism among cancer experts about the relevance of genetics. Various contributors acknowledge their predecessors in the field, especially staff at St Mark’s Hospital who pioneered research into familial adenomatous polyposis. This condition, in which multiple benign polyps appear in the bowel, was first suspected to be pre-cancerous by St Mark’s doctors and led to the foundation of the hospital’s Polyposis Register of patients in 1924. These early pathological records enabled, and stimulated, the international research community to undertake family linkages and genetic studies, thus contributing to the eventual identification of a polyposis gene in 1991. Equally prominent in the discussion is hereditary non-polyposis colorectal cancer, as are questions of research funding and collaborations, and the development of specific diagnostic tests and therapeutic approaches.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesWellcome Witnesses to Contemporary Medicine;Volume 46
dc.subjectHistory of Modern Biomedicine Research Groupen_US
dc.subjectWellcome Witnesses to Contemporary Medicineen_US
dc.titleClinical Cancer Genetics: Polyposis and Familial Colorectal Cancer c.1975-c.2010en_US
dc.typeBooken_US


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