Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
4653 - 4660
Hum Mol Genet
MetadataShow full item record
To discover quantitative trait loci for intraocular pressure, a major risk factor for glaucoma and the only modifiable one, we performed a genome-wide association study on a discovery cohort of 2175 individuals from Sydney, Australia. We found a novel association between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. The findings in this region were confirmed through two UK replication cohorts totalling 4866 individuals (rs59072263, P(combined) = 1.10 × 10(-8)). A copy of the G allele at this SNP is associated with an increase in mean IOP of 0.45 mmHg (95%CI = 0.30-0.61 mmHg). These results lend support to the implication of vesicle trafficking and glucocorticoid inducibility pathways in the determination of intraocular pressure and in the pathogenesis of primary open-angle glaucoma.
AuthorsBlue Mountains Eye Study (BMES),; Wellcome Trust Case Control Consortium 2 (WTCCC2),
- College Publications 
Showing items related by title, author, creator and subject.
Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos. Sofer, T; Wong, Q; Hartwig, FP; Taylor, K; Warren, HR; Evangelou, E; Cabrera, CP; Levy, D; Kramer, H; Lange, LA;... (Nature Publishing Group, 2017-11-02)Hypertension prevalence varies between ethnic groups, possibly due to differences in genetic, environmental, and cultural determinants. Hispanic/Latino Americans are a diverse and understudied population. We performed a ...
Fidler, JA; Shahab, L; West, O; Jarvis, MJ; McEwen, A; Stapleton, JA; Vangeli, E; West, R (2011)BACKGROUND: Up-to-date data tracking of national smoking patterns and cessation-related behaviour is required to evaluate and inform tobacco control strategies. The Smoking Toolkit Study (STS) was designed for this role. ...
Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery. Wijeysundera, DN; Pearse, RM; Shulman, MA; Abbott, TE; Torres, E; Croal, BL; Granton, JT; Thorpe, KE; Grocott, MP; Farrington, C;... (2016-03-11)INTRODUCTION: Preoperative functional capacity is considered an important risk factor for cardiovascular and other complications of major non-cardiac surgery. Nonetheless, the usual approach for estimating preoperative ...