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    Informing treatment decisions through meta-analysis: to network or not? 
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    Informing treatment decisions through meta-analysis: to network or not?

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    Published version
    Embargoed until: 5555-01-01
    Reason: Cannot archive publisher's version
    Volume
    22
    Pagination
    12 - 15
    DOI
    10.1136/ebmed-2016-110599
    Journal
    Evid Based Med
    Issue
    1
    Metadata
    Show full item record
    Abstract
    Evidence from randomised trials and their meta-analyses is typically formed of head-to-head comparisons of a couple of treatments; multiarm trials are infrequent. However, in real-life healthcare, there are many more than two treatment options for a particular condition. To be relevant for the shop-floor of practice, evidence-based medicine requires the use a comprehensive approach to compile, compare and contrast evidence on all options in one synthesis. Network meta-analysis (NMA) offers exactly such a solution. It generates a rank order of the available treatments for practitioners and policymakers that has the merit of objectivity. However, reviewers should make transparent the limitations of NMA as it uses direct and indirect comparisons, inevitably collating data with a certain degree of heterogeneity. This approach is increasingly being deployed to underpin evidence syntheses for incorporating research into practice.
    Authors
    Al Wattar, BH; Zamora, J; Khan, KS
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/23503
    Collections
    • Centre for Primary Care and Public Health [1461]
    Language
    eng
    Copyright statements
    Copyright © 2016 The Author(s). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
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