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dc.contributor.authorMarques, Pen_US
dc.contributor.authorKorbonits, Men_US
dc.date.accessioned2017-05-10T09:34:30Z
dc.date.available2017-05-02en_US
dc.date.issued2017-06en_US
dc.date.submitted2017-04-12T23:04:17.585Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/22763
dc.description.abstractAlthough most of pituitary adenomas are benign, they may cause significant burden to patients. Sporadic adenomas represent the vast majority of the cases, where recognized somatic mutations (eg, GNAS or USP8), as well as altered gene-expression profile often affecting cell cycle proteins have been identified. More rarely, germline mutations predisposing to pituitary adenomas -as part of a syndrome (eg, MEN1 or Carney complex), or isolated to the pituitary (AIP or GPR101) can be identified. These alterations influence the biological behavior, clinical presentations and therapeutic responses, and their full understanding helps to provide appropriate care for these patients.en_US
dc.format.extent335 - 374en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofEndocrinol Metab Clin North Amen_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAIPen_US
dc.subjectCarney complexen_US
dc.subjectFIPAen_US
dc.subjectGeneticsen_US
dc.subjectMEN1en_US
dc.subjectMEN4en_US
dc.subjectPituitary tumoren_US
dc.subjectXLAGen_US
dc.subjectAdenomaen_US
dc.subjectHumansen_US
dc.subjectMutationen_US
dc.subjectPituitary Glanden_US
dc.subjectPituitary Neoplasmsen_US
dc.titleGenetic Aspects of Pituitary Adenomas.en_US
dc.typeArticle
dc.rights.holder© 2017 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.ecl.2017.01.004en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28476226en_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume46en_US


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