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dc.contributor.authorSubramanian, Len_US
dc.contributor.authorNakamura, TMen_US
dc.date.accessioned2017-03-24T15:29:11Z
dc.date.issued2010-06-01en_US
dc.date.submitted2017-03-01T09:36:06.263Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/22225
dc.description.abstractDNA damage checkpoint and DNA repair mechanisms play critical roles in the stable maintenance of genetic information. Various forms of DNA damage that arise inside cells due to common errors in normal cellular processes, such as DNA replication, or due to exposure to various DNA damaging agents, must be quickly detected and repaired by checkpoint signaling and repair factors. Telomeres, the natural ends of linear chromosomes, share many features with undesired "broken" DNA, and are recognized and processed by various DNA damage checkpoint and DNA repair proteins. However, their modes of action at telomeres must be altered from their actions at other DNA damage sites to avoid telomere fusions and permanent cell cycle arrest. Interestingly, accumulating evidence indicates that DNA damage checkpoint and DNA repair proteins are essential for telomere maintenance. In this article, we review our current knowledge on various mechanisms by which DNA damage checkpoint and DNA repair proteins are modulated at telomeres and how they might contribute to telomere maintenance in eukaryotes.en_US
dc.format.extent1105 - 1118en_US
dc.languageengen_US
dc.relation.ispartofFront Biosci (Landmark Ed)en_US
dc.relation.replaces123456789/22226
dc.relation.replaceshttps://qmro.qmul.ac.uk/handle/123456789/22226
dc.subjectAnimalsen_US
dc.subjectDNA Damageen_US
dc.subjectDNA Repairen_US
dc.subjectDNA Repair Enzymesen_US
dc.subjectDNA Replicationen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectHumansen_US
dc.subjectMRE11 Homologue Proteinen_US
dc.subjectProtein Bindingen_US
dc.subjectTelomeraseen_US
dc.subjectTelomereen_US
dc.titleTo fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?en_US
dc.typeArticle
dc.rights.holder© Front Biosci
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/20515744en_US
pubs.merge-from123456789/22226
pubs.merge-fromhttps://qmro.qmul.ac.uk/handle/123456789/22226
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume15en_US


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